Greek Study Shows REGIONS OF THE BRAIN IMPACTED BY EMF

by Paris08, Thursday, January 26, 2012, 15:21 (2336 days ago)
edited by admin, Friday, January 27, 2012, 03:16

Greek Study Shows Regions of the Brain Related to Learning, Memory, Alzheimer's Impacted by EMF

Electromagnetic Biology and Medicine, Early Online: 1-25, 2012.

A study led by Adamantia Fragopoulou and Lukas Margaritis has demonstrated important protein changes in the brain of animals following whole body exposure to RF electromagnetic fields, similar to the kind of microwave radiation emitted from cell phones, portable phones, WiFi and wireless computer equipment.

Important regions of the brain necessary for learning, memory and other functions of the mammalian brain were impacted by the microwave radiation, including the hippocampus, cerebellum and frontal lobe, at exposures below the ICNIRP (International Commission on Non-Ionizing Radiation Protection) safety guidelines. A total of 143 proteins in the brain were impacted by the RF radiation over a period of 8 months, providing new evidence for a potential relationship between everyday cell phone use, wireless transmitters and wireless computer equipment and electrosensitivity symptoms, such as headaches, dizziness and sleep disorders, as well as with tumors, Alzheimer's and even metabolic effects.

The study simulated 3 hours of cell phone exposure over eight months, 8 hours of DECT portable phone exposure over eight months, and included a sham exposure control group. The results showed both down regulation and up regulation of the proteins.

Several neural function related proteins (i.e. Glial Fibrillary Acidic Protein (GFAP), Alpha-synuclein, Glia Maturation Factor beta (GMF), and apolipoprotein E (apoE)), heat shock proteins, and cytoskeletal proteins (i.e. neurofilaments and tropomodulin), were shown to be impacted by the radiation, as well as proteins of the brain metabolism (i.e. Aspartate aminotransferase, Glutamate dehydrogenase), in nearly all of the brain regions studied. …

Abstract:
Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation
Adamantia F. Fragopoulou1, Athina Samara2, Marianna H. Antonelou1, Anta Xanthopoulou3, Aggeliki Papadopoulou3, Konstantinos Vougas3, Eugenia Koutsogiannopoulou2, Ema Anastasiadou2, Dimitrios J. Stravopodis1, George Th. Tsangaris3 & Lukas H. Margaritis1
1Department of Cell Biology and Biophysics, Athens University, Athens, Greece, 2Genetics and Gene Therapy Division, Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece, and 3Proteomics Research Unit, Center of Basic Research II, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

The objective of this study was to investigate the effects of two sources of electromagnetic fields (EMFs) on the proteome of cerebellum, hippocampus, and frontal lobe in Balb/c mice following long-term whole body irradiation. Three equally divided groups of animals (6 animals/group) were used; the first group was exposed to a typical mobile phone, at a SAR level range of 0.17- 0.37 W/kg for 3 h daily for 8 months, the second group was exposed to a wireless DECT base (Digital Enhanced Cordless Telecommunications/Telephone) at a SAR level range of 0.012- 0.028 W/kg for 8 h/day also for 8 months and the third group comprised the sham-exposed animals. Comparative proteomics analysis revealed that long-term irradiation from both EMF sources altered significantly (p , 0.05) the expression of 143 proteins in total (as low as 0.003 fold downregulation up to 114 fold overexpression). Several neural function related proteins (i.e., Glial Fibrillary Acidic Protein (GFAP), Alpha-synuclein, Glia Maturation Factor beta (GMF), and apolipoprotein E (apoE)), heat shock proteins, and cytoskeletal proteins (i.e., Neurofilaments and tropomodulin) are included in this list as well as proteins of the brain metabolism (i.e., Aspartate aminotransferase, Glutamate dehydrogenase) to nearly all brain regions studied. Western blot analysis on selected proteins confirmed the proteomics data. The observed protein expression changes may be related to brain plasticity alterations, indicative of oxidative stress in the nervous system or involved in apoptosis and might potentially explain human health hazards reported so far, such as headaches, sleep disturbance, fatigue, memory deficits, and brain tumor long-term induction under similar exposure conditions.

Media may request a copy of the study from Adamantia Fragopoulou, Lukas Margaritis, Corresponding Authors, at madofrag@biol.uoa.gr, lmargar@biol.uoa.gr

Sources and more information:
Faculty of Biology, University of Athens and the Biomedical Research Foundation of the Academy of Athens;
http://electromagnetichealth.org/electromagnetic-health-blog/mice-proteome/

Dariusz Leszczynski comment..........

by Bob, Wednesday, February 01, 2012, 04:36 (2330 days ago) @ Paris08

• Greek proteomics study on effect of cell phone radiation on mice brain

Few days ago research group from Greece published study that examined effects of cell phone radiation and DECT phone radiation on mice brain using proteomics approach. After exposure to radiation, that was generated by regular phones connected to network and playing music, mice brains were examined for changes in expression levels of hundreds of proteins.

Greek researchers concluded that both cell phone radiation and DECT phone radiation alters amounts of over 100 proteins in mice brain. In the press release researchers pointed out that the affected proteins are important in regulation of learning, memory and in regulation of processes leading to Alzheimer’s disease.

Unfortunately, the Greek study falls far from the target.

The only effect that was somewhat shown is the possibility that cell phone radiation might alter levels of some brain proteins. The indication of the processes that might be affected was a pure speculation because the data obtained from the proteomic analysis were insufficiently confirmed. Certain proteins were named as affected but the confirmation experiments that the change is real were not performed.

Analysis of changes in protein expression was performed using 2D-electrophoresis followed by detection of proteins by coomassie blue staining. Thereafter, the images of stained gels were analyzed using the PDQuest software. This is already “obsolete” approach.
Read more:
http://betweenrockandhardplace.wordpress.com/2012/01/29/%e2%80%a2greek-proteomics-study...

Dariusz Leszczynski comment + Igor Beliaev's Reply

by Paris08, Monday, February 13, 2012, 12:03 (2318 days ago) @ Bob

Re: Greek Study Shows Regions of the Brain Related to Learning, Memory, Alzheimer's Impacted by EMF

A Greek study led by Adamantia Fragopoulou and Lukas Margaritis has demonstrated important protein changes in the brain of animals following whole body exposure to RF electromagnetic fields, similar to the kind of microwave radiation emitted from cell phones, portable phones, WiFi and wireless computer equipment. The study, was published in Electromagnetic Biology and Medicine, Early Online: 1-25, 2012


Comments by Dr. Igor Beliaev:

… » I have read carefully the proteomic paper by Fragopoulou et al 2012. While the remarks of Dariusz Leszczynski on proteomics are in general correct, they are hardly applied to this paper, because the paper is actually one of the best, if not the best, in research of MW effects using proteomics.

Igor Beliaev, Dr.Sc.
Cancer Research Institute
Slovak Academy of Science
Vlárska 7, 833 91 Bratislava
Slovak Republic

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